Biochemical or molecular optimization

Why ?

  • There is a very high incidence of biochemical disorders on the neuro-atypical population, in particular on patients with ASD, ADHD.  

  • The studies also shed light on the genetic abnormalities of neurodevelopmental disorders, responsible for example for reduced synthesis of proteins, neurotransmitters, etc.

  • Brain plasticity can be enhanced by acting on a biochemical level

How? 'Or' What ?

  • Knowing the individual biochemical profile by blood, urine and DNA analyzes makes it possible to set up any suitable treatments  

  • Reduce disorders or improve performance at molecular and cellular level to improve brain or muscle performance

  • Strengthen brain energy performance, by boosting the functioning of mitochondria

  • Strengthen brain performance by reducing inflammation

  • Promote brain plasticity at the cellular and molecular level

  • Reduce epilepsy

What approaches?

  1. Functional medicine 

  2. Assessment of biochemical disorders, inflammations, intoxications, mitochondrial insufficiency, insufficient protein synthesis

  3. Microbiota evaluation and optimization, such as Viome

  4. Biomedical and nutritional approaches, such as Walsh protocol, Nutritional Balancing, ketogenic diets, Gasp

  5. Naturopathy, aromatherapy, food supplements and adaptogens

  6. Microbiota transfer or fecal transplantation

  7. HBOT (Hyperbaric Oxygen Therapy)

  8. H2 Molecular hydrogen: Trusii

  9. Light therapy, Bioptrom, infrared therapy

  10. Stem cell infusion

Main scientific publications

Walsh Research Institute (WJ Walsh, Ph.D), studies based on the analysis of the largest database of biochemical analyzes (results of more than 1.5 million chemical analyzes of blood, urine and tissues, on a panel of 6,500 ASD patients, 10,000 ADHD patients in particular).

The collision of undermethylation, epigenetics and oxidative stress in autism spectrum disorders , WJ Walsh, Ph.D, Walsh Research Institute (Autism One presentation)

Biochemical and Nutritional Interventions for ADHD and Behavioral Disorder ,  WJ Walsh, Ph.D, Walsh Research Institute

How nutritional status, diet and dietary supplements can affect autism: a review , Kawicka A1, Regulska-Ilow B.

Autism and Dietary Therapy: Case Report and Review of the Literature . Herbert, MR, Buckley, JA Journal of Child Neurology. 2013.

Translational Implications of a Whole-Body Approach to Brain Health in Autism: How Transduction between Metabolism and Electrophysiology Points to Mechanisms for Neuroplasticity , Herbert, MR, Frontiers in Autism Research: New Horizons for Diagnosis and Treatment. 2014

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis, Rossignol, Frye 2011

Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging, Goh S , Dong Z 2011

mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disorders, Oberman, 2011

The use of medications approved for Alzheimer's disease in autism spectrum disorder: a systematic review , Rossignol, Frye, 2012

The Role of Omega-3 Fatty Acids in Developmental Psychopathology: A Systematic Review on Early Psychosis, Autism, and ADHD, Agostoni C , Nobile , 2017

Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism, Eshraghi, Deth, 2018

Potential therapeutic use of the ketogenic diet in autism spectrum disorders , Department of Molecular Biosciences, University of California Davis, 2014

The Gut Microbiota and Autism Spectrum Disorders Qinrui Li , Ying Han , Front. Cell. Neurosci., April 28, 2017

The microbiome revolution , Martin J. Blaser, J Clin Invest . 2014

 

Partial synthesis 

Very high incidence of biochemical disorders on the neuro-atypical population (vs the average of the population), indicating the need to know the individual biochemical profile of the patient (blood, urine, DNA analyzes) in order to set up appropriate treatments. 

Research shows in particular:

ASD patients (autism spectrum disorders)

  • Under-methylation:> 95% of ASD patients vs 4% average population, it is a factor of over-expression of genes, epigenetic errors are accentuated by abnormal methylation

  • Oxidative stress  :> 85%

  • Copper level too high and low ceruloplasmin:> 95% of ASD patients, causes an increase in norepinephrine levels, which is one of the factors of epilepsy

  • Zinc and metallothionein deficiency

  • High level of toxic metals

  • Stress-oxidant is the cause of hypersensitivity to toxic metals, to certain proteins such as casein, gluten, weak immune system, dysfunction of methylation, inflammatory reactions

  • Oxidative stress is an important factor in impaired brain development: high oxidative stress depletes glutathione, sufficient glutathione is necessary for the proper functioning of metallothionein, which is a key factor in early brain development (development neurons, but also pruning ...)

  • Biochemical abnormalities (difference vs population mean) are greater in ASD patients than in patients suffering from mental illness (depression or even schizophrenia)

  • Professor Walsh talks about the vicious circle of autism: hypomethylation // epigenetic errors, triggered by environmental attacks (on a fragile system that fails to defend itself) // oxidative stress.

ADHD patients (attention deficit hyperactivity disorder)

  • Copper level too high (68%): the excess of Cu acts on the depletion of the levels of  dopamine, the weak function of this neurotransmitter leads to ADHD.

  • Zinc deficiency (96%)

  • Insufficient ceruloplasmin (92%)

  • Under or over-methylation (55%)

  • Pyroluria (30%)

  • Malabsorption (11%) 

  • The biochemical treatment varies according to the individual biochemical profile, for example: 

    • Increase neurotransmission at dopamine and GABA receptors, inhibit expression of DAT reuptake proteins and promote GABA synthesis, increase intake of methionine, Zinc, vitamin B-6 

    • Reduce neurotransmission of norepinephrine and epinephrine, normalize levels of Copper / Zinc, vitamins B-6, B-12